Does Kratom have dangers?

Mitragyna speciosa or Kratom is having its fame today. The kratom tree is large tree native to South East Asian countries particularly Thailand and Malaysia. The natives used the leaves of kratom for medicinal purposes such as dealing with pain and treating diarrhea. In rehabilitation, people who are dependents on opiates and morphine are experiencing withdrawal symptoms when they stop taking the drugs. Medical approach was proven to use kratom as an alternative to opium and morphine. It was proven that giving kratom in low dose then gradually lessened until total withdrawal results to milder and safer withdrawal symptoms compared to withdrawal symptoms from morphine and opiates. There are other benefits that kratom claims to provide. They say that kratom is a great stimulant therefore the natives used it as a sexual stimulant, improving and enhancing their sexual activity. It can also create a mild effect for the minds. All of these effects are made possible by the alkaloid contents of kratom such as mitragyne.
The kratom leaves are chewed, smoked and boiled as tea by the natives. They have used the leaves for a long period of time now and no records show that someone had suffered negatively in taking kratom. There are no official records about addiction to kratom but they say that dependence to it is possible. Taking kratom in low doses is safe but ingesting higher dose regularly for a long time may produce undesirable results. The body may develop a tolerance against the alkaloids found in mitragyna, creating a need to increase the dose to achieve the desired effects. There is an overdose of kratom. Some say that an individual may experience hallucinations, nausea, delusion, tremors, coordination problems and restlessness. Daily intake of kratom for a long time may result to skin darkening, aggression, nervousness and constipation. Kratom is not recommended to be use by people having schizophrenia, cardiac, renal, ulcers, hepatic problems, low blood pressure and pregnant women.

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What are the benefits of Kratom?

Kratom has been used for centuries. Today, the health and medical world is giving attention to kratom. Independent studies from different laboratories are being conducted to study the effects of kratom to human consumption. In the studies, kratom contains alkaloids that have effects on the human mind. It has stimulating, depressing and intoxicating effects. Pharmaceuticals are exerting some efforts in creating kratom-based medicines such as topicals and pain relievers. This is very upsetting to us, Pharmaceutical companies have a LOT of say in government issues when it comes to banning Kratom. The leaves are smoked, chewed and prepared as teas by boiling.

Taking kratom in a controlled, low dose certain benefits are said to be acquired. Kratom was used by jungle people to restore their lost energy. They say that kratom can restore energy, making you active and stronger. The natives Thai used the leaves of kratom to treat diarrhea and muscle pain. Others say that it can lower blood pressure suitable for people with hypertension. It also contains a substance called epicatechin, a substance found in dark chocolates that can promote good health. Mitragyna is said to be a good stimulant therefore others use it as sexual enhancer to improve their sexual activity. It is also use to treat people having depressions. Kratom can create a soothing effect, relaxing and calming the mind. They also used kratom to protect them from extreme effects of the sun by stimulating the production of melanin. Some users of kratom say that they use kratom as tea to lose weight for it has effect to the appetite. Definitely, kratom is such a discovery and it has a great future in the world of health that's why the health and drug industry is investing time and money for it.

 

Kratom Resin

WHAT IS KRATOM EXTRACT?

 

We hope to answer the following questions, What is Kratom Extract? How are extracts made? What is actually in kratom extract? There are 3 ways we see Kratom.  We see Kratom as a crushed leaf, in powder form, or the extracted form which is called an extract. For the purpose of this article, the definition of extract in a chemistry sense is to obtain (a substance) from a mixture or material by a chemical or physical process, such as digestion, distillation, the action of a solvent, or mechanical separation. We are going to try and explain what a Kratom extract is since most vendors have some sort of extract on their list of products. For now, The Leaping Leaf extracts solely to enhance plain leaf Kratom so it still very affordable.  You can find these under our Lightly Enhanced Blends section and our Boldly Enhanced Blends sections. If you have ever been to a vitamin or supplement shop, chances are you have seen extracts of some sort. There are lots of plant extracts since so many plants have wonderful medicinal uses. The “extract” that is being pulled from the plant are known as alkaloids and it is these alkaloids that make up the useful part of the plant. Check out our other post with a little info on the Alkaloids that make up Kratom. There are at least 10,000 known alkaloids!  There are about 28 different alkaloids in Kratom (also known as Mitragyna Speciosa), and there is still a lot of studying that needs to be done to fully understand the alkaloids. The geographical region and other variables determine the alkaloids present in the different known Kratom strains.

Used in our FX series

You have probably did your own extraction sometime in your life. Have you ever brewed Coffee or Tea? Then you’ve extracted before. Extraction can be done with water, alcohol (used for Kratom Tincture), and Acetic Acid to name a few.

 

The Alkaloids in Kratom make up only about .5% while the other 99.5% is just filler. To give you an idea of why extract is so strong and can be expensive, if you were to get all the alkaloid out of Kratom, it would take 450kg to make around 2.5kg of pure Kratom alkaloid extract. Note: We aren’t referring to Kratom Resin. We’ll discuss Kratom Resin in the future. While scientists are continually finding new and awesome uses of many Kratom Alkaloids, the Alkaloids the Kratom burners are interested in are are   7-hydroxymitragynine, and Mitragynine. It used to be thought that Mitragynine was the main alkaloid but scientists now believe it to be 7-hydroxymitragynine. Studies have shown the this alkaloid is a WHOPPING 46x more active then mitragynine! 

Believe it or not, the different extraction methods determine which alkaloids are extracted out of the Kratom leaf the best. Using water to extract alkaloids is different from using alcohol to extract alkaloids.

But most people want all the alkaloids to be present, extracts that contain the same amount of ALL the alkaloids in Kratom is known as Full Spectrum Kratom extracts. There are lots of other Katom extracts as well though. These extracts are usually concentrating on certain Alkaloids, not an equal amount of all of them like Full Spectrum Extract. Full Spectrum Extract is basically a more potent form of a kratom leaf but the other extracts that concentrate on only certain alkaloids usually go for the mitragynine or 7-hydroxymitragynine Alkaloids first and foremost.

Most people mix their Kratom extract with plain leaf which creates an "Enhanced Blend" of Kratom. This is our specialty. This makes the extract go much further for your money.

What is 10x extract, 25x extract, 50x extract, and 100x extract?

Have you ever seen a site selling (some number)X extract on a website? It's really freaking confusing isn't it? This number followed by "X" is suppose to be the concentration of the Kratom extract. Most of the misconceptions surrounding kratom extracts are due to this :"X" . Some Kratom vendors tell their customers this "X" means "times" like in math.  So they claim that 1g of 10x kratom extract is 10 times as active as 1 gram of kratom powder. This is incorrect, and this unfortunate mismarketing of kratom extract has led many to decry kratom extracts as ineffective or fraudulent. What this "X" really means is the amount of Kratom leaf it takes to make the extract so as an example, 25g of 10x extract means it took 250g of Kratom Leaf to make that 25g of Kratom extract. So you are clear what this means, 25g of 30x extract takes 750g of Kratom leaf to make. You get the picture now, that is why extract isn't cheap. But, now does that mean this 25g of 30X extract has 30 times more alkaloid in it? The answer is no because the extraction process isn't perfect. The folks that make Kratom extract use all kind of different methods, machine, solvents, etc. Some alkaloids are undoubtedly more extract than others so the "X" really is meaningless, if the extractor used some cheap ole 19th century method in the 30x example(750g), he will not get the same amount of allkaloids as some $300,000 machine doing the extraction. Plus, since each extraction method works better for certain alkaloids then others, you still don't know what you getting.

The other thing you need to remember is one vendor's 15X extract may not be as good or may be better than another vendor's 15X extract. What in the world is the deal with these really high numbers like 100X extract. Be safe and buy a very small amount before wasting your money.

 

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What Makes Kratom work?
What Alkaloids are in Kratom?

Basically the same question put two different ways. So what is tt that makes Kratom such an awesome plant? Kratom leaves are made up of Alkaloids. Each different strains contains diffrent amounts of these alkaloids and each alkaloid has a different role in creating the aroma that Kratom creates. There is still ALOT of studying that needs to be done by scientists to dig deeper into this subject. Here is a list of know alkaloids in Kratom and their potential effect for the aroma.

Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.

Akuammigine

Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.

Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.

Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.

Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.

Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.

9-Hydroxycorynantheidine: Partial opioid agonist

7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.

Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.

Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Isopteropodine: Immunostimulant

Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.

Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.

Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.

Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.

Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.

Mitraversine

Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.

Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.

Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.

Speciofoline

Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.

Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.

Stipulatine

Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)

Mitragyna speciosa Kratom alkaloid content varies quantitatively from geographical location, and from month to month, at different leaf harvest times, which has lead some teams (Shellard et al. in the 1970s) to conclude that there may be different geographical variants within the same species.

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